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In the current review, we documented the identification and also the characterization of a whole new atypical opioid receptor with unique detrimental regulatory Attributes towards opioid peptides.1 Our outcomes showed that ACKR3/CXCR7, hitherto often called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a broad-spectrum sc